Absolutely! WSE RemoteApp works just fine when your client computers are not domain joined.

That being said, WSE RemoteApp works best if you set up your non-joined client computers so that they use the exact same sign in credentials as the server’s user account. For example, if your user name on the server is “Joe“, and your password is “joe’spassword1234“, then use those exact same credentials to sign in to your client computer as well. Doing so, will make things go much smoother for the end user.

However, if you prefer to use a Microsoft account to sign in to your client computers, or if you choose to use a different set of sign in credentials than what’s being used for the user over on the Essentials server, then the user will first need to open the Launchpad application (by right-clicking on the Windows Server Essentials Connector icon that appears down in the notification area of the Taskbar, and choosing “Open Launchpad“), and sign in there before they will be able to successfully connect to WSE RemoteApp (i.e. it will require one extra sign in).